2013-2017

  1. Kim CK,* Ye L*, Jennings JH, Pichamoorthy N, Tang DD, Wang AC, Ramakrishnan C, Deisseroth K. Molecular and Circuit-dynamical Identification of Top-down Neural Mechanisms for Restraint of Reward-seeking. Cell. 2017 Aug 24;170(5):1013-1027.e14. (Highlighted by Nature Reviews Neuroscience)

  2. Ye L*, Allen WE*, Thompson KR*, Tian Q, Hsueh B, Ramakrishnan C, Wang AC, Jennings JH, Adhikari A, Halpern CH, Witten IB, Barth AL, Luo L, McNab JA, Deisseroth K. Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences. Cell. 2016 Jun 16;165(7):1776-88. (Cover Story and Highlighted by Cell) 

  3. Lerner TN, Ye L, Deisseroth K. Communication in Neural Circuits: Tools, Opportunities and Challenges. Cell. 2016 Mar 10;164(6):1136-50

  4. Tomer R, Ye L, Hsueh B, Deisseroth K. Advanced CLARITY for rapid and high-resolution imaging of intact tissues. Nat Protoc. 2014 Jul;9(7):1682-97

  5. Cadavieco M*, Gorbati M*, Ye L, Kosse C, Börgers C, Veldt S, Lee SY, Ramakrishnan C, Denisova N, Ramm F, Hu Y, Bender F, Burdakov D, Deisseroth K, Ponomarenko A & Korotkova T. Gamma oscillations organize top-down signalling to hypothalamus and enable food seeking.  Nature. 2017 Feb 9;542(7640):232-236.

  6. Hsueh B, Burns V, Pauerstein P, Holzem K, Ye L, Engberg K, Wang AC, Gu X, Chakravarthy H, Arda HE, Charville G, Vogel H, Efimov IR, Kim S & Deisseroth K. Pathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease. Scientific Reports, 2017 Jul 19;7(1):5899.

  7. Adhikari A, Lerner TN, Finkelstein J, Pak S, Jennings JH, Davidson TJ, Ferenczi E, Gunaydin LA, Mirzabekov JJ, Ye L, Kim SY, Lei A, Deisseroth K. Basomedial amygdala mediates top-down control of anxiety and fear. Nature. 2015, Nov 12;527(7577):179-85.

  8. Font-Burgada J, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell. 2015 Aug 13;162(4):766-79.

  9. Hsiang HL, Epp JR, van den Oever MC, Yan C, Rashid AJ, Insel N, Ye L, Niibori Y, Deisseroth K, Frankland PW, Josselyn SA. Manipulating a "cocaine engram" in mice. J Neurosci. 2014 Oct 15;34(42):14115-27.

  10. Zhang MD, Tortoriello G, Hsueh B, Tomer R, Ye L, Mitsios N, Borgius L, Grant G, Kiehn O, Watanabe M, Uhlén M, Mulder J, Deisseroth K, Harkany T, Hökfelt TG. Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):E1149-58.

2007-2013

  1. Ye L, Wu J, Cohen P, Kazak L, Khandekar MJ, Jedrychowski MP, Zeng X, Gygi SP and Spiegelman BM. Fat cells directly sense temperature to activate thermogenesis. Proc Natl Acad Sci U S A. July 1, 2013, 10.1073 (Highlighted in Nature, Science, and PNAS)

  2. Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P,  Khandekar MJ, Boström P, Mepani R, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE and Spiegelman BM. TRPV4 is a regulator of adipose oxidative metabolism, inflammation and energy homeostasis. Cell. 2012 Sep 28;151(1):96-110. (Highlighted in Nature Medicine, Science Signaling, and Nature Reviews Drug Discovery)

  3. Cohen P, Levy JD, Zhang Y, Frontini A, Lo JC,  Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, and Spiegelman BM.  Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch. Cell. 2014 Jan 16;156(1-2):304-16

  4. Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang A, Khandekar M, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P and Spiegelman BM. Beige Adipocytes are a Distinct Type of Thermogenic Fat Cell in Mouse and Human. Cell. 2012 Jul 20;150(2):366-76.

  5. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012 Jan 1;481(7382):463-8.

  6. Kleiner S, Mepani RJ, Laznik D, Ye L, Jurczak MJ, Jornayvaz FR, Estall JL, Chatterjee Bhowmick D, Shulman GI, Spiegelman BM. Development of insulin resistance in mice lacking PGC-1α in adipose tissues. Proc Natl Acad Sci U S A. 2012 May 29.

  7. Gupta RK, Mepani RJ, Kleiner S, Lo JC, Khandekar MJ, Cohen P, Frontini A, Bhowmick DC, Ye L, Cinti S, Spiegelman BM. Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metab. 2012 Feb 8;15(2):230-9.

  8. Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM. Transcriptional control of preadipocyte determination by Zfp423. Nature. 2010 Mar 25;464:619-23.

  9. Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metab. 2011 Feb 2;13(2):160-9

  10. Han J, Qureshi AA, Prescott J, Guo Q, Ye L, Hunter DJ, De Vivo I. A prospective study of telomere length and the risk of skin cancer. J Invest Dermatol. 2009 Feb;129(2):415-21

(*co-first authors)

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